All 3 of my dogs have had reactions to this product, i.e., skin burning and infection on site of application, agitation, vomiting, diarhea, foaming at mouth, drooling, neurological ticks, etc. My 3rd smaller dog had a more severe reaction and needed emergency care. There's no way to determine at this point whether the effects are going to be long term and permanent. This product needs to be recalled before it kills more animals.